Featured publications
Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry
November 28, 2023
Yang F, Suo M, Weli H, Wong M, Junidi A, Cummings C, Johnson R, Mallory K, Liu AY, Greenberg ZJ, Schuettpelz LG, Miller MJ, Luke CJ, Randolph GJ, Zinselmeyer BH, Wardenburg JB, Clemens RA. Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry. Cell Rep. 2023 Nov 28;42(11):113394. doi: 10.1016/j.celrep.2023.113394. Epub 2023 Nov 10. PMID: 37950870; PMCID: PMC10731421.
ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense
September 29, 2020
Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA. ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24403-24414. doi: 10.1073/pnas.2008032117. Epub 2020 Sep 14. PMID: 32929002; PMCID: PMC7533673.
STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production
September 28, 2017
Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA. STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production. Blood. 2017 Sep 28;130(13):1565-1577. doi: 10.1182/blood-2016-11-751230. Epub 2017 Jul 19. PMID: 28724541; PMCID: PMC5620414.
STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense
April 3, 2014
Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014 Apr 3;123(14):2238-49. doi: 10.1182/blood-2012-08-450403. Epub 2014 Feb 3. PMID: 24493668; PMCID: PMC3975260.
Recent publications
- Investigating pulmonary neutrophil responses to inflammation in mice via flow cytometrySong, Z., Clemens, R. A., Zhang, Y., Chen, J., Wang, Y., Dinauer, M. C. & Meng, S., Mar 1 2025, In: Journal of Leukocyte Biology. 117, 3, qiae189.Research output: Contribution to journal › Article › peer-review
- Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal diseaseWalker, E. C., Javati, S., Todd, E. M., Matlam, J. P., Lin, X., Bryant, M., Krone, E., Ramani, R., Chandra, P., Green, T. P., Anaya, E. P., Zhou, J. Y., Alexander, K. A., Tong, R. S., Yuasi, L., Boluarte, S., Yang, F., Greenberg, L., Nerbonne, J. M. & Greenberg, M. J. & 10 others, Clemens, R. A., Philips, J. A., Wilson, L. D., Halabi, C. M., DeBosch, B. J., Blyth, C. C., Druley, T. E., Kazura, J. W., Pomat, W. S. & Morley, S. C., Dec 2024, In: Nature immunology. 25, […]
- Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entryYang, F., Suo, M., Weli, H., Wong, M., Junidi, A., Cummings, C., Johnson, R., Mallory, K., Liu, A. Y., Greenberg, Z. J., Schuettpelz, L. G., Miller, M. J., Luke, C. J., Randolph, G. J., Zinselmeyer, B. H., Wardenburg, J. B. & Clemens, R. A., Nov 28 2023, In: Cell Reports. 42, 11, 113394.Research output: Contribution to journal › Article › peer-review
- Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidaseSong, Z., Bhattacharya, S., Clemens, R. A. & Dinauer, M., Oct 20 2023, In: iScience. 26, 10, 108034.Research output: Contribution to journal › Review article › peer-review
- Neutrophil DREAM promotes neutrophil recruitment in vascular inflammationLi, J., Kumari, T., Barazia, A., Jha, V., Jeong, S. Y., Olson, A., Kim, M., Lee, B. K., Manickam, V., Song, Z., Clemens, R., Razani, B., Kim, J., Dinauer, M. C. & Cho, J., Nov 9 2021, In: Journal of Experimental Medicine. 219, 1, e20211083.Research output: Contribution to journal › Article › peer-review
- Surface proteins of SARS-CoV-2 drive airway epithelial cells to induce IFN-dependent inflammationAnand, G., Perry, A. M., Cummings, C. L., Raymond, E. S., Clemens, R. A. & Steed, A. L., Jun 15 2021, In: Journal of Immunology. 206, 12, p. 3000-3009 10 p.Research output: Contribution to journal › Article › peer-review
- A sustained type i ifn-neutrophil-il-18 axis drives pathology during mucosal viral infectionLebratti, T., Lim, Y. S., Cofie, A., Andhey, P., Jiang, X., Scott, J., Fabbrizi, M. R., Ozantürk, A. N., Pham, C., Clemens, R., Artyomov, M., Dinauer, M. & Shin, H., May 2021, In: eLife. 10, e65762.Research output: Contribution to journal › Article › peer-review
- A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsisKangelaris, K. N., Clemens, R., Fang, X., Jauregui, A., Liu, T., Vessel, K., Deiss, T., Sinha, P., Leligdowicz, A., Liu, K. D., Zhuo, H., Alder, M. N., Wong, H. R., Calfee, C. S., Lowell, C. & Matthay, M. A., May 2021, In: American Journal of Physiology – Lung Cellular and Molecular Physiology. 320, 5, p. L892-L902Research output: Contribution to journal › Article › peer-review
- Extrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injuryLeonard, J. M., Zhang, C. X., Lu, L., Hoofnagle, M. H., Fuchs, A., Clemens, R. A., Ghosh, S., Hughes, S. W., Bochicchio, G. V., Hotchkiss, R. & Turnbull, I. R., 2021, In: Journal of Trauma and Acute Care Surgery. 90, 6, p. 924-934 11 p.Research output: Contribution to journal › Article › peer-review
- ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defenseGrimes, D., Johnson, R., Pashos, M., Cummings, C., Kang, C., Sampedro, G. R., Tycksen, E., McBride, H. J., Sah, R., Lowell, C. A. & Clemens, R. A., Sep 29 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 39, p. 24403-24414 12 p.Research output: Contribution to journal › Article › peer-review