Recent publications
A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection
May 28, 2022
Lebratti T, Lim YS, Cofie A, Andhey P, Jiang X, Scott J, Fabbrizi MR, Ozantürk AN, Pham C, Clemens R, Artyomov M, Dinauer M, Shin H. A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection. Elife. 2021 May 28;10:e65762. doi: 10.7554/eLife.65762. PMID: 34047696; PMCID: PMC8163503.
Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation
January 3, 2022
Li J, Kumari T, Barazia A, Jha V, Jeong SY, Olson A, Kim M, Lee BK, Manickam V, Song Z, Clemens R, Razani B, Kim J, Dinauer MC, Cho J. Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation. J Exp Med. 2022 Jan 3;219(1):e20211083. doi: 10.1084/jem.20211083. Epub 2021 Nov 9. PMID: 34751735; PMCID: PMC8719643.
Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation
June 15, 2021
Anand G, Perry AM, Cummings CL, St Raymond E, Clemens RA, Steed AL. Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation. J Immunol. 2021 Jun 15;206(12):3000-3009. doi: 10.4049/jimmunol.2001407. Epub 2021 Jun 2. PMID: 34078711; PMCID: PMC8278276.
Extrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injury
June 1, 2021
Leonard JM, Zhang CX, Lu L, Hoofnagle MH, Fuchs A, Clemens RA, Ghosh S, Hughes SW, Bochicchio GV, Hotchkiss R, Turnbull IR. Extrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injury. J Trauma Acute Care Surg. 2021 Jun 1;90(6):924-934. doi: 10.1097/TA.0000000000003147. PMID: 34016916; PMCID: PMC8932930.
A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis
May 1, 2021
Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA. A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L892-L902. doi: 10.1152/ajplung.00090.2020. Epub 2020 Dec 23. PMID: 33355521; PMCID: PMC8174834.